Invention Grant
- Patent Title: Azole compound
- Patent Title (中): 唑类化合物
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Application No.: US13054057Application Date: 2009-07-13
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Publication No.: US08207199B2Publication Date: 2012-06-26
- Inventor: Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
- Applicant: Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JPP2008-182251 20080714
- International Application: PCT/JP2009/062680 WO 20090713
- International Announcement: WO2010/007966 WO 20100121
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; C07D417/14 ; C07D401/14 ; C07D413/14

Abstract:
A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
Public/Granted literature
- US20110118311A1 AZOLE COMPOUND Public/Granted day:2011-05-19
Information query
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