Invention Grant
- Patent Title: Benzamide compounds useful as histone deacetylase inhibitors
- Patent Title (中): 可用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
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Application No.: US12090611Application Date: 2006-10-17
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Publication No.: US08207202B2Publication Date: 2012-06-26
- Inventor: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- Applicant: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- Applicant Address: SE Sodertalje
- Assignee: Astrazeneca AB
- Current Assignee: Astrazeneca AB
- Current Assignee Address: SE Sodertalje
- Agency: Astrazeneca AB
- Priority: GB0521244.4 20051019
- International Application: PCT/GB2006/003838 WO 20061017
- International Announcement: WO2007/045844 WO 20070426
- Main IPC: A61K31/454
- IPC: A61K31/454 ; C07D401/06

Abstract:
The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
Public/Granted literature
- US20080269294A1 Benzamide Compounds Useful as Histone Deacetylase Inhibitors Public/Granted day:2008-10-30
Information query
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