Invention Grant
US08207298B2 Methods of separating biopolymer conjugated molecules from unconjugated molecules
有权
将生物聚合物共轭分子与未共轭分子分离的方法
- Patent Title: Methods of separating biopolymer conjugated molecules from unconjugated molecules
- Patent Title (中): 将生物聚合物共轭分子与未共轭分子分离的方法
-
Application No.: US12434170Application Date: 2009-05-01
-
Publication No.: US08207298B2Publication Date: 2012-06-26
- Inventor: Paul Hatala , William J. Issa
- Applicant: Paul Hatala , William J. Issa
- Applicant Address: US MA Cambridge
- Assignee: Archemix Corp.
- Current Assignee: Archemix Corp.
- Current Assignee Address: US MA Cambridge
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi
- Main IPC: B01D15/34
- IPC: B01D15/34 ; C07H1/06 ; C07K1/14
Abstract:
The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
Public/Granted literature
- US20090286955A1 Methods of Separating Biopolymer Conjugated Molecules From Unconjugated Molecules Public/Granted day:2009-11-19
Information query
