Invention Grant
- Patent Title: Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses
- Patent Title (中): 针对突变P53的常见表位的人合成单链抗体及其用途
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Application No.: US13180581Application Date: 2011-07-12
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Publication No.: US08207309B2Publication Date: 2012-06-26
- Inventor: Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
- Applicant: Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
- Applicant Address: IL Tel-Aviv
- Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee Address: IL Tel-Aviv
- Main IPC: C12P21/08
- IPC: C12P21/08
Abstract:
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
Public/Granted literature
- US20110262447A1 HUMAN SYNTHETIC SINGLE-CHAIN ANTIBODIES DIRECTED AGAINST THE COMMON EPITOPE OF MUTANT P53 AND THEIR USES Public/Granted day:2011-10-27
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