Invention Grant
US08207315B2 Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
有权
与血管生成和内皮细胞特异性凋亡相关的基因和蛋白质
- Patent Title: Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
- Patent Title (中): 与血管生成和内皮细胞特异性凋亡相关的基因和蛋白质
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Application No.: US10569744Application Date: 2004-08-20
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Publication No.: US08207315B2Publication Date: 2012-06-26
- Inventor: Qing K. Wang , Xiao-Li Tian , Rajkumar Kadaba
- Applicant: Qing K. Wang , Xiao-Li Tian , Rajkumar Kadaba
- Applicant Address: US OH Cleveland
- Assignee: The Cleveland Clinic Foundation
- Current Assignee: The Cleveland Clinic Foundation
- Current Assignee Address: US OH Cleveland
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2004/027324 WO 20040820
- International Announcement: WO2005/019432 WO 20050303
- Main IPC: C07H21/02
- IPC: C07H21/02
Abstract:
This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
Public/Granted literature
- US20080199473A1 Novel Gene and Protein Associated With Angiogenesis and Endothelial Cell-Specific Apoptosis Public/Granted day:2008-08-21
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