Invention Grant
US08207321B2 Method of obtaining idolocarbazoles using biosynthetic rebeccamycin genes
有权
使用生物合成rebeccamycin基因获得idolocarbazoles的方法
- Patent Title: Method of obtaining idolocarbazoles using biosynthetic rebeccamycin genes
- Patent Title (中): 使用生物合成rebeccamycin基因获得idolocarbazoles的方法
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Application No.: US10493000Application Date: 2002-10-17
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Publication No.: US08207321B2Publication Date: 2012-06-26
- Inventor: César Sánchez Reillo , Alfredo Fernandez Braña , José Antonio Salas Fernandez , Carmen Mendez Fernandez
- Applicant: César Sánchez Reillo , Alfredo Fernandez Braña , José Antonio Salas Fernandez , Carmen Mendez Fernandez
- Applicant Address: ES Oviedo
- Assignee: Universidad De Oviedo
- Current Assignee: Universidad De Oviedo
- Current Assignee Address: ES Oviedo
- Agency: Ladas & Parry LLP
- Priority: ES0102312 20011019
- International Application: PCT/ES02/00492 WO 20021017
- International Announcement: WO03/033706 WO 20030424
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C07H21/00 ; C12P1/00 ; C12N1/12 ; C12N15/00
Abstract:
Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
Public/Granted literature
- US20080004326A1 Method of Obtaining Idolocarbazoles Using Biosynthetic Rebeccamycin Genes Public/Granted day:2008-01-03
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