Invention Grant
- Patent Title: Process for preparing montelukast and salts thereof
- Patent Title (中): 孟鲁司特及其盐的制备方法
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Application No.: US12673916Application Date: 2009-05-25
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Publication No.: US08207343B2Publication Date: 2012-06-26
- Inventor: Venkata Sunil Kumar Indukuri , Srinivas Simhadri , Satyanarayana Chava
- Applicant: Venkata Sunil Kumar Indukuri , Srinivas Simhadri , Satyanarayana Chava
- Applicant Address: IN Hyderabad
- Assignee: Laurus Labs Private Limited
- Current Assignee: Laurus Labs Private Limited
- Current Assignee Address: IN Hyderabad
- Agency: Blank Rome LLP
- Priority: IN1284/CHE/2008 20080526
- International Application: PCT/IN2009/000299 WO 20090525
- International Announcement: WO2009/144742 WO 20091203
- Main IPC: C07D215/18
- IPC: C07D215/18
Abstract:
A method for the preparation of montelukast and salts thereof has been described. The method comprises of following steps: (a) (S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl methane sulphonate (styrene mesylate salt) (b) coupling with 1-(mercapto methyl)cyclopropane acetic acid followed by salification with an amine gives styrene amine salt (c) Converting styrene amine salt to Montelukast amine salt (d) Converting Montelukast amine salt to Montelukast free acid and or its required alkali/alkaline salt.
Public/Granted literature
- US20110112300A1 IMPROVED PROCESS FOR PREPARING MONTELUKAST AND SALTS THEREOF Public/Granted day:2011-05-12
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