Invention Grant
US08207354B2 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
有权
制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
- Patent Title: Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
- Patent Title (中): 制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
-
Application No.: US12919842Application Date: 2009-02-27
-
Publication No.: US08207354B2Publication Date: 2012-06-26
- Inventor: Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
- Applicant: Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Hofer Gilson & Lione
- Priority: EP08102197 20080229
- International Application: PCT/EP2009/052378 WO 20090227
- International Announcement: WO2009/106619 WO 20090903
- Main IPC: C07D231/10
- IPC: C07D231/10 ; C07C69/00

Abstract:
A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
Public/Granted literature
- US20110004002A1 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates Public/Granted day:2011-01-06
Information query