Invention Grant
US08207354B2 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法

Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
Abstract:
A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting  where M is a sodium or potassium ion, and  without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
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