Invention Grant
US08207356B2 Method for the preparation of (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
失效
制备（S）-N-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺盐酸盐（度洛西汀）的方法
- Patent Title: Method for the preparation of (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
- Patent Title (中): 制备（S）-N-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺盐酸盐（度洛西汀）的方法
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Application No.: US13253441Application Date: 2011-10-05
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Publication No.: US08207356B2Publication Date: 2012-06-26
- Inventor: Ludek Ridvan , Kamal Jarrah , Josef Cinibulk , Monika Zatopkova , Lukas Placek
- Applicant: Ludek Ridvan , Kamal Jarrah , Josef Cinibulk , Monika Zatopkova , Lukas Placek
- Applicant Address: CZ Praha
- Assignee: Zentiva k.s.
- Current Assignee: Zentiva k.s.
- Current Assignee Address: CZ Praha
- Agency: Pearl Cohen Zedek Latzer, LLP
- Priority: CSPV2006-7 20060104
- Main IPC: C07D333/20
- IPC: C07D333/20
Abstract:
A method for the preparation of a duloxetine hydrochloride salt from a duloxetine base, comprising the steps of: reacting duloxetine base with concentrated hydrochloric acid in ethylmethylketone; and crystallizing duloxetine hydrochloride salt from said concentrated hydrochloric acid in ethylmethylketone.
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