Invention Grant
- Patent Title: Gene disruptions, compositions and methods relating thereto
- Patent Title (中): 基因破坏，组合物和方法
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Application No.: US13031009Application Date: 2011-02-18
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Publication No.: US08207396B2Publication Date: 2012-06-26
- Inventor: Bobby Joe Payne , Mary Jean Sparks , Wen Xiong
- Applicant: Bobby Joe Payne , Mary Jean Sparks , Wen Xiong
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Bonny Yeung; Christopher De Vry
- Main IPC: G01N33/00
- IPC: G01N33/00
Abstract:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
Public/Granted literature
- US20110173708A1 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO Public/Granted day:2011-07-14
Information query
