Invention Grant
- Patent Title: Nucleotide sequences encoding enzymes in biosynthesis of dihydroartemisinic acid
- Patent Title (中): 编码二氢青蒿酸生物合成酶的核苷酸序列
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Application No.: US12225556Application Date: 2007-04-04
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Publication No.: US08207402B2Publication Date: 2012-06-26
- Inventor: Keat (Thomas) H. Teoh , Darwin R. Reed , Devin R. Polichuk , Patrick S. Covello
- Applicant: Keat (Thomas) H. Teoh , Darwin R. Reed , Devin R. Polichuk , Patrick S. Covello
- Applicant Address: CA Ottawa, Ontario
- Assignee: National Research Council of Canada
- Current Assignee: National Research Council of Canada
- Current Assignee Address: CA Ottawa, Ontario
- Agency: National Research Council of Canada
- International Application: PCT/CA2007/000614 WO 20070404
- International Announcement: WO2007/112596 WO 20071011
- Main IPC: C12N15/29
- IPC: C12N15/29 ; C12N15/52 ; C12N15/82
Abstract:
Isolated nucleic acid molecules cloned from Artemisia annua encode artemisinic aldehyde double bond reductase and artemisinic/dihydroartemisinic aldehyde dehydrogenase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to dihydroartemisinic aldehyde. Artemisinic/dihydroartemisinic aldehyde dehydrogenase enzymatically oxidizes dihydroartemisinic aldehyde to dihydroartemisinic acid and artemisinic aldehyde to artemisinic acid. The nucleic acid molecules, and the enzymes encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde, dihydroartemisinic acid or artemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the a antimalarial compound artemisinin.
Public/Granted literature
- US20090265804A1 NUCLEOTIDE SEQUENCES ENCODING ENZYMES IN BIOSYNTHESIS OF DIHYDROARTEMISINIC ACID Public/Granted day:2009-10-22
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