An enclosure is provided for a musical instrument, particularly for a guitar. The enclosure has a flexible rear panel having a laterally enlarged lower portion to cover the back side of the guitar. The enclosure further includes a flexible front side being substantially of the same size and shape as the rear side of the enclosure. A side panel, which is substantially continuous, interconnects the rear side and the front side of the enclosure. Preferably, the front side is clear or transparent so that the guitar may be viewed from outside the enclosure. An opening is provided in the bottom of the side wall and the opening is sized and shaped to allow the passage of the guitar in and out of the enclosure.