Provided is a semiconductor device in which the first trench isolation regions is placed between a substrate potential-fixing P-type diffusion region of an ESD protection NMOS transistor and source and drain regions of the ESD protection NMOS transistor, and has a depth greater than a depth of the second trench isolation region that is placed between a substrate potential-fixing P-type diffusion region of an NMOS transistor for internal circuit and source and drain regions of the NMOS transistor for internal circuit.