A semiconductor memory device includes a first bitline pair equalized to a first voltage level by a first equalizer circuit, a second bitline pair equalized to a second voltage level by a second equalizer circuit, an isolation circuit disposed between the first bitline pair and the second bitline pair, the isolation unit configured to electrically connect or isolate the first bitline pair to or from the second bitline pair, and a sense amplifier electrically connected to the second bitline pair, the sense amplifier configured to sense a voltage difference of the second bitline pair, wherein the isolation circuit isolates one of the connections between the first bitline pair and the second bitline pair while the sense amplifier senses the voltage difference of the second bitline pair.