A technique for use in angiography includes obtaining data from a tracking scan following injection of a contrast agent according to a test injection profile. A region of interest (308) is established. The data from the tracking scan, the test injection profile, and the measured enhancement of the region of interest (302) are used to establish a patient function at the region of interest. The patient function and a desired enhancement profile (402) are used to establish a desired clinical injection profile. The desired clinical injection profile is communicated to a contrast injector (36) via an electrical injector interface.