An MRI-guided interventional system includes a head support apparatus for engaging and securing the head of a patient, and a targeting frame configured to be secured to the body of a patient. The targeting frame includes a cooperating targeting cannula that is configured to guide placement of an interventional device through a burr hole in a patient's skull in vivo. The system includes an MRI-compatible camera positioned proximate to the head support apparatus, and an MRI-compatible imaging device having one end attached to the targeting frame to provide a local field of view of the burr hole, and an opposite end in communication with the camera. The system also includes a display output module coupled to the camera for receiving electrical signals therefrom and for displaying images corresponding thereto.