An object of the invention is to provide a braking control system of a two-wheeled motor vehicle, by which when a front-and-rear-wheel-interlocked brake operates, operation feeling of a brake lever is improved, and consequently more natural operation feeling may be provided. A braking control system of a two-wheeled motor vehicle according to the invention performs front-and-rear-wheel-interlocked braking control that allows a front-wheel brake and a rear-wheel brake to operate in an interlocked manner. The front-wheel brake is configured of a front-wheel first brake and a front-wheel second brake. ECU 400 controls a front-wheel hydraulic circuit 100 so that the first brake operates according to the front-and-rear-wheel-interlocked braking control. Furthermore, the ECU 400 controls the front-wheel hydraulic circuit 100 so that the front-wheel second brake receives hydraulic pressure caused along with operation of a brake lever 101 during performing the front-and-rear-wheel-interlocked braking control. Thus, operation feeling of the brake lever 101 is improved.