A needle stick protection device includes a housing shaped and dimensioned for positioning about a syringe including a needle extending therefrom. The housing includes a first housing member telescopically coupled to a second housing member. The first housing member includes a first end shaped and dimensioned for receiving the syringe and a second end. The second housing member includes a first end and a substantially closed second end. The second end includes an aperture shaped and dimensioned to permit the passage of the needle therethrough. A locking assembly is associated with the first housing member and the second housing member for selectively controlling movement of the first housing member relative to the second housing member.