Invention Grant
- Patent Title: Mutant having uracil phosphoribosyl transferase activity
- Patent Title (中): 具有尿嘧啶磷酸核糖基转移酶活性的突变体
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Application No.: US12495492Application Date: 2009-06-30
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Publication No.: US08211421B2Publication Date: 2012-07-03
- Inventor: Philippe Erbs , Richard Jund
- Applicant: Philippe Erbs , Richard Jund
- Applicant Address: FR Illkirch
- Assignee: Transgene S.A.
- Current Assignee: Transgene S.A.
- Current Assignee Address: FR Illkirch
- Agency: Buchanan Ingersoll & Rooney PC
- Priority: FR9805054 19980417
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/70 ; A01N65/00 ; C12N5/00 ; C12N15/00
Abstract:
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
Public/Granted literature
- US20100316610A1 MUTANT HAVING URACIL PHOSPHORIBOSYL TRANSFERASE ACTIVITY Public/Granted day:2010-12-16
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