Invention Grant
- Patent Title: Recombinant P. falciparum merozoite protein-142 vaccine
- Patent Title (中): 重组恶性疟原虫裂殖子蛋白-142疫苗
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Application No.: US12507004Application Date: 2009-07-21
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Publication No.: US08211447B2Publication Date: 2012-07-03
- Inventor: Evelina Angov , Jeffrey A. Lyon , Christian Asare Darko , Joe D. Cohen
- Applicant: Evelina Angov , Jeffrey A. Lyon , Christian Asare Darko , Joe D. Cohen
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee Address: US DC Washington
- Agent Elizabeth Arwine
- Main IPC: A61K39/015
- IPC: A61K39/015 ; A61K38/00
Abstract:
In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-142. The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.
Public/Granted literature
- US20100028386A1 RECOMBINANT P. FALCIPARUM MEROZOITE PROTEIN-142 VACCINE Public/Granted day:2010-02-04
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