Invention Grant
- Patent Title: Endosomolytic polymers
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Application No.: US11533115Application Date: 2006-09-19
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Publication No.: US08211468B2Publication Date: 2012-07-03
- Inventor: David B. Rozema , Darren H. Wakefield , Jon A. Wolff , James E. Hagstrom , Kirk Ekena
- Applicant: David B. Rozema , Darren H. Wakefield , Jon A. Wolff , James E. Hagstrom , Kirk Ekena
- Applicant Address: US WI Madison
- Assignee: Arrowhead Madison Inc.
- Current Assignee: Arrowhead Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- Main IPC: A61K9/32
- IPC: A61K9/32 ; C07D207/444
Abstract:
We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
Public/Granted literature
- US20070036865A1 Endosomolytic Polymers Public/Granted day:2007-02-15
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