Invention Grant
- Patent Title: P53 modulator and cancer target
- Patent Title (中): P53调节剂和癌症靶标
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Application No.: US12667314Application Date: 2008-07-03
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Publication No.: US08211635B2Publication Date: 2012-07-03
- Inventor: Michelle Barton
- Applicant: Michelle Barton
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski L.L.P.
- Priority: GB0723246.5 20071127
- International Application: PCT/IB2008/002504 WO 20080703
- International Announcement: WO2009/004484 WO 20090108
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
Methods of screening for modulators of TRIM24 (also known as TIF1-ALPHA) expression and/or biological activity are described. In particular, methods of screening of screening for modulators of TRIM24 E3 ligase activity, and specifically an E3 ligase activity directed at p53 as the target polypeptide are also described. Modulators of TRIM24 expression and activity are provided and their use in treatment of cancer, particularly in breast, colon, prostate, renal cancers and in acute lymphoblastic leukaemia. Suitable modulators of TRIM24 expression include siRNA and shRNA and can be used in the treatment of cancer and for targeting cancer stem cells.
Public/Granted literature
- US20100189725A1 P53 MODULATOR AND CANCER TARGET Public/Granted day:2010-07-29
Information query
