Invention Grant
US08211858B2 Modified plasminogen activator inhibitor type-1 molecule and methods based thereon
有权
修饰的纤溶酶原激活物抑制剂1型分子及其基础的方法
- Patent Title: Modified plasminogen activator inhibitor type-1 molecule and methods based thereon
- Patent Title (中): 修饰的纤溶酶原激活物抑制剂1型分子及其基础的方法
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Application No.: US12597686Application Date: 2008-04-24
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Publication No.: US08211858B2Publication Date: 2012-07-03
- Inventor: Jerzy Jankun , Ewa Skrzypczak-Jankun , Steven H. Selman
- Applicant: Jerzy Jankun , Ewa Skrzypczak-Jankun , Steven H. Selman
- Applicant Address: US OH Toledo
- Assignee: The University of Toledo
- Current Assignee: The University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2008/005272 WO 20080424
- International Announcement: WO2009/014564 WO 20090129
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K1/00
Abstract:
The present invention relates to a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI-1, but is deficient in one or more functional activities as compared to the wild-type PAI-1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following functional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-1 molecules and methods of using these pharmaceutical compositions for treatment.
Public/Granted literature
- US20100184667A1 MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON Public/Granted day:2010-07-22
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