Invention Grant
US08211859B2 α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
失效
α-半乳糖苷类似物，其制造方法，可用于这些方法的中间体化合物和含有它们的药物组合物
- Patent Title: α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
- Patent Title (中): α-半乳糖苷类似物，其制造方法，可用于这些方法的中间体化合物和含有它们的药物组合物
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Application No.: US12446431Application Date: 2007-10-18
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Publication No.: US08211859B2Publication Date: 2012-07-03
- Inventor: Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
- Applicant: Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
- Applicant Address: FR Paris FR Paris FR Paris
- Assignee: Centre National de la Recherche Scientifique,Universite Paris Descartes,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Centre National de la Recherche Scientifique,Universite Paris Descartes,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris FR Paris FR Paris
- Agency: Morgan, Lewis & Bockius LLP
- Priority: WOPCT/IB2006/003929 20061018
- International Application: PCT/IB2007/004270 WO 20071018
- International Announcement: WO2008/047249 WO 20080424
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70
Abstract:
The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
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