Invention Grant
- Patent Title: Paramyxovirus vector encoding angiogenesis gene and use thereof
- Patent Title (中): 编码血管发生基因的副粘病毒载体及其用途
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Application No.: US13049011Application Date: 2011-03-16
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Publication No.: US08211868B2Publication Date: 2012-07-03
- Inventor: Yoshikazu Yonemitsu , Katsuo Sueishi , Masayuki Fukumura , Xiaogang Hou , Mamoru Hasegawa , Hidenori Matsusaka , Hiroyuki Tsutsui
- Applicant: Yoshikazu Yonemitsu , Katsuo Sueishi , Masayuki Fukumura , Xiaogang Hou , Mamoru Hasegawa , Hidenori Matsusaka , Hiroyuki Tsutsui
- Applicant Address: JP Ibaraki
- Assignee: DNAVEC Research Inc.
- Current Assignee: DNAVEC Research Inc.
- Current Assignee Address: JP Ibaraki
- Agency: Clark & Elbing LLP
- Priority: JP2000-359374 20001127
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
The present invention provides Paramyxovirus vectors encoding angiogenic genes and use of the same. The use of Paramyxovirus vectors enables effective transfer of angiogenic genes into individual tissues. FGF2 gene transferred into ischemic tissues in vivo induces expression of angiogenic genes without causing edema, and prevents necrosis due to ischemia. The vectors of the present invention are suitable for gene therapy targeted to ischemic tissues.
Public/Granted literature
- US20110212059A1 PARAMYXOVIRUS VECTOR ENCODING ANGIOGENESIS GENE AND USE THEREOF Public/Granted day:2011-09-01
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