Invention Grant
US08211885B2 Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
有权
环吲哚-3-甲酰胺，它们的制备及其作为药物的用途
- Patent Title: Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
- Patent Title (中): 环吲哚-3-甲酰胺，它们的制备及其作为药物的用途
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Application No.: US12845317Application Date: 2010-07-28
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Publication No.: US08211885B2Publication Date: 2012-07-03
- Inventor: Henning Steinhagen , Bodo Scheiper , Hans Matter , Hans Ulrich Stilz , Gary McCort
- Applicant: Henning Steinhagen , Bodo Scheiper , Hans Matter , Hans Ulrich Stilz , Gary McCort
- Applicant Address: FR Paris
- Assignee: Sanofi-Aventis
- Current Assignee: Sanofi-Aventis
- Current Assignee Address: FR Paris
- Agent Ronald G. Ort
- Priority: EP08290093 20080131
- Main IPC: A61K31/551
- IPC: A61K31/551 ; A61K31/496 ; C07D209/42 ; C07D401/04 ; C07D401/06 ; C07D405/04 ; C07D409/04
Abstract:
The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20110039830A1 CYCLIC INDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2011-02-17
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