Invention Grant
US08211891B2 Difluoromethyl-containing macrocyclic compounds as hepatitis C virus inhibitors
有权
含二氟甲基的大环化合物作为丙型肝炎病毒抑制剂
- Patent Title: Difluoromethyl-containing macrocyclic compounds as hepatitis C virus inhibitors
- Patent Title (中): 含二氟甲基的大环化合物作为丙型肝炎病毒抑制剂
-
Application No.: US12433191Application Date: 2009-04-30
-
Publication No.: US08211891B2Publication Date: 2012-07-03
- Inventor: Yonghua Gai , Dong Liu , Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant: Yonghua Gai , Dong Liu , Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore, Esq.
- Main IPC: C07D225/00
- IPC: C07D225/00 ; C07D295/00 ; A61K31/495 ; A61P31/22
Abstract:
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20090274657A1 DIFLUOROMETHYL-CONTAINING MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS Public/Granted day:2009-11-05
Information query
