Invention Grant
- Patent Title: Capped pyrazinoylguanidine sodium channel blockers
- Patent Title (中): 封闭的吡嗪基胍钠通道阻滞剂
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Application No.: US12876615Application Date: 2010-09-07
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Publication No.: US08211895B2Publication Date: 2012-07-03
- Inventor: Michael R. Johnson , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
- Applicant: Michael R. Johnson , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
- Applicant Address: US NC Durham
- Assignee: Parion Sciences, Inc.
- Current Assignee: Parion Sciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07D241/02
Abstract:
The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure: or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.
Public/Granted literature
- US20110003832A1 NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS Public/Granted day:2011-01-06
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