Invention Grant
US08211904B2 Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用于治疗阿尔茨海默氏病的Spiropiperidineβ-分泌酶抑制剂
- Patent Title: Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
- Patent Title (中): 用于治疗阿尔茨海默氏病的Spiropiperidineβ-分泌酶抑制剂
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Application No.: US11487229Application Date: 2006-07-14
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Publication No.: US08211904B2Publication Date: 2012-07-03
- Inventor: Craig A. Coburn , Melissa S. Egbertson , Samuel L. Graham , Georgia B. McGaughey , Shaun R. Stauffer , Hemaka A. Rajapakse , Philippe G. Nantermet , Shawn J. Stachel , Wenjin Yang , Wanli Lu , Bruce Fahr
- Applicant: Craig A. Coburn , Melissa S. Egbertson , Samuel L. Graham , Georgia B. McGaughey , Shaun R. Stauffer , Hemaka A. Rajapakse , Philippe G. Nantermet , Shawn J. Stachel , Wenjin Yang , Wanli Lu , Bruce Fahr
- Applicant Address: US NJ Rahway US CA South San Francisco
- Assignee: Merck, Sharp & Dohme Corp.,Sunesis Pharmaceuticals, Inc.
- Current Assignee: Merck, Sharp & Dohme Corp.,Sunesis Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Rahway US CA South San Francisco
- Agent Keith D. MacMillan; Gerard M. Devlin
- Main IPC: A61K31/438
- IPC: A61K31/438 ; C07D401/04 ; C07D403/04
Abstract:
The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Public/Granted literature
- US20070021454A1 Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease Public/Granted day:2007-01-25
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