Invention Grant
US08211916B2 N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
有权
N-和O-取代的4- [2-（二苯基甲氧基） - 乙基] -1 - [（苯基）甲基]哌啶类似物及其治疗CNS病症的方法
![N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith](/docs/US/2012-07-03/US08211916B2/abs.jpg.600x600.jpg)
- Patent Title: N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
- Patent Title (中): N-和O-取代的4- [2-（二苯基甲氧基） - 乙基] -1 - [（苯基）甲基]哌啶类似物及其治疗CNS病症的方法
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Application No.: US12018172Application Date: 2008-01-22
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Publication No.: US08211916B2Publication Date: 2012-07-03
- Inventor: Aloke K. Dutta
- Applicant: Aloke K. Dutta
- Applicant Address: US MI Detroit
- Assignee: Wayne State University
- Current Assignee: Wayne State University
- Current Assignee Address: US MI Detroit
- Agency: Brooks Kushman P.C.
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D211/40
![N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith](/abs-image/US/2012/07/03/US08211916B2/abs.jpg.150x150.jpg)
Abstract:
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl] piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SERT and between the DAT and the norepinephrine transporter (NET). The compounds have utility in treating CNS disorders, including but not limited to cocaine addiction, depression, and Parkinson's disease.
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