Invention Grant
US08211920B2 6-oxo-1,6-dihydropyridine derivatives as inhibitors of MEK and methods of use thereof
有权
6-氧代-1,6-二氢吡啶衍生物作为MEK的抑制剂及其使用方法
- Patent Title: 6-oxo-1,6-dihydropyridine derivatives as inhibitors of MEK and methods of use thereof
- Patent Title (中): 6-氧代-1,6-二氢吡啶衍生物作为MEK的抑制剂及其使用方法
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Application No.: US12186273Application Date: 2008-08-05
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Publication No.: US08211920B2Publication Date: 2012-07-03
- Inventor: Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
- Applicant: Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agent John R. Moore, Esq.; Sarah S. Mastous
- Main IPC: C07D213/74
- IPC: C07D213/74 ; C07D213/75 ; C07D213/55 ; C07D213/56 ; A61K31/4412
Abstract:
Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases and inflammatory conditions in mammals and pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20090215834A1 HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF Public/Granted day:2009-08-27
Information query
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