Invention Grant
- Patent Title: Heterocyclic inhibitors of MEK and methods of use
- Patent Title (中): MEK的杂环抑制剂及其使用方法
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Application No.: US12356428Application Date: 2009-01-20
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Publication No.: US08211921B2Publication Date: 2012-07-03
- Inventor: James F. Blake , Joseph P. Lyssikatos , Allison L. Marlow , Jeongbeob Seo , Eli M. Wallace , Hong-Woon Yang
- Applicant: James F. Blake , Joseph P. Lyssikatos , Allison L. Marlow , Jeongbeob Seo , Eli M. Wallace , Hong-Woon Yang
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris & Padys PLLP
- Agent John R. Moore, Esq.; Sarah S. Mastous
- Main IPC: A61K31/4412
- IPC: A61K31/4412 ; C07D213/80 ; C07D213/82 ; A61K31/4965 ; C07D241/28
Abstract:
Disclosed are compounds of the Formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, W, and X are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20090131435A1 HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE Public/Granted day:2009-05-21
Information query
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