Invention Grant
US08211927B2 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators
失效
5-苯基 - 异恶唑-3-甲酰胺衍生物作为TRPV1调节剂
- Patent Title: 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators
- Patent Title (中): 5-苯基 - 异恶唑-3-甲酰胺衍生物作为TRPV1调节剂
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Application No.: US12671113Application Date: 2008-07-31
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Publication No.: US08211927B2Publication Date: 2012-07-03
- Inventor: Andrew Laird Roughton , Koc-Kan Ho , Michael Ohlmeyer , Irina Neagu , Steven G. Kultgen , Nasrin Ansari , Yajing Rong , Paul David Ratcliffe , Ronald Palin
- Applicant: Andrew Laird Roughton , Koc-Kan Ho , Michael Ohlmeyer , Irina Neagu , Steven G. Kultgen , Nasrin Ansari , Yajing Rong , Paul David Ratcliffe , Ronald Palin
- Applicant Address: NL Oss
- Assignee: MSD, Oss B.V.
- Current Assignee: MSD, Oss B.V.
- Current Assignee Address: NL Oss
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/EP2008/060090 WO 20080731
- International Announcement: WO2009/016241 WO 20090205
- Main IPC: A61K31/42
- IPC: A61K31/42 ; C07D261/18
Abstract:
The present invention relates to isoxazole-3-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carboxamide derivatives for the treatment of TRPV1 mediated disorders, such as acute and chronic pain disorders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders.
Public/Granted literature
- US20110065764A1 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS Public/Granted day:2011-03-17
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