Invention Grant
- Patent Title: Antagonists of the transient receptor potential vanilloid 1 and uses thereof
- Patent Title (中): 瞬时受体潜在香草酸1的拮抗剂及其用途
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Application No.: US12082598Application Date: 2008-04-11
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Publication No.: US08211941B2Publication Date: 2012-07-03
- Inventor: Pankaj J. Pasricha , Jiande Chen , Rami Hawari
- Applicant: Pankaj J. Pasricha , Jiande Chen , Rami Hawari
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Landrum Intellectual Property
- Main IPC: A61K31/216
- IPC: A61K31/216

Abstract:
One of the major disabling symptoms of gastroparesis is nausea and vomiting which can be difficult to control with currently available treatments. It is postulated that signaling of gastrointestinal causes of nausea starts with activation of vagal afferent nerves that trigger the central emetic pathway. Most vagal afferent nerves are unmyelinated C-fibers, many of which express the vanilloid receptor TRPV1 and respond to capsaicin. Resiniferatoxin is a very potent capsaicin analogue that has a much more favorable ratio of desensitization to excitation than capsaicin leading to more effective desensitization without irritation. The present invention describes methods of alleviating acute or chronic nausea, vomiting by the administration of resiniferatoxin.
Public/Granted literature
- US20090012154A1 Antagonists of the transient receptor potential vanilloid 1 and uses thereof Public/Granted day:2009-01-08
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