Invention Grant
- Patent Title: Sphingosine 1-phosphate antagonism
- Patent Title (中): 鞘氨醇1-磷酸拮抗作用
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Application No.: US12391664Application Date: 2009-02-24
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Publication No.: US08212010B2Publication Date: 2012-07-03
- Inventor: Deron R. Herr , Greg L. Harris
- Applicant: Deron R. Herr , Greg L. Harris
- Applicant Address: US CA Cardiff
- Assignee: Expression Drug Designs, LLC
- Current Assignee: Expression Drug Designs, LLC
- Current Assignee Address: US CA Cardiff
- Agency: Arent Fox, LLP
- Agent Patricia Granados
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12N15/07 ; G01N33/53
Abstract:
Materials and Method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of sphingosine-1-phosphate receptor subtype 3 are provided.
Public/Granted literature
- US20090226453A1 SPHINGOSINE 1-PHOSPHATE ANTAGONISM Public/Granted day:2009-09-10
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