Invention Grant
US08212042B2 Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease
有权
喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病
- Patent Title: Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease
- Patent Title (中): 喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病
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Application No.: US12084467Application Date: 2006-05-19
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Publication No.: US08212042B2Publication Date: 2012-07-03
- Inventor: Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
- Applicant: Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2005-0110261 20051117
- International Application: PCT/KR2006/001889 WO 20060519
- International Announcement: WO2007/073021 WO 20070628
- Main IPC: C07D215/24
- IPC: C07D215/24
Abstract:
The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
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