Invention Grant
US08212045B2 Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
有权
吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物作为葡萄糖激酶激活剂用于治疗糖尿病
- Patent Title: Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
- Patent Title (中): 吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物作为葡萄糖激酶激活剂用于治疗糖尿病
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Application No.: US12678995Application Date: 2008-09-15
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Publication No.: US08212045B2Publication Date: 2012-07-03
- Inventor: Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
- Applicant: Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma, Inc.
- Current Assignee: Array BioPharma, Inc.
- Current Assignee Address: US CO Boulder
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2008/076401 WO 20080915
- International Announcement: WO2009/042435 WO 20090402
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D417/00
Abstract:
Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
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