Invention Grant
- Patent Title: Dual-acting benzoimidazole antihypertensive agents
- Patent Title (中): 双效苯并咪唑抗高血压药
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Application No.: US12330289Application Date: 2008-12-08
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Publication No.: US08212052B2Publication Date: 2012-07-03
- Inventor: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D235/08

Abstract:
The invention relates to compounds having the formula: wherein Ar, r, n, X, R2, R2′, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
Public/Granted literature
- US20090149521A1 DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2009-06-11
Information query
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