Invention Grant
- Patent Title: Process for preparing 2-amino-5-cyanobenzoic acid derivatives
- Patent Title (中): 制备2-氨基-5-氰基苯甲酸衍生物的方法
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Application No.: US12741635Application Date: 2008-11-07
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Publication No.: US08212075B2Publication Date: 2012-07-03
- Inventor: Vladimir Grushin , Albert Loren Casalnuovo
- Applicant: Vladimir Grushin , Albert Loren Casalnuovo
- Applicant Address: US DE Wilmington
- Assignee: E.I. du Pont de Nemours and Company
- Current Assignee: E.I. du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Agent Renee M. Lett
- International Application: PCT/US2008/082739 WO 20081107
- International Announcement: WO2009/061991 WO 20090514
- Main IPC: C07C231/12
- IPC: C07C231/12

Abstract:
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with at least one alkali metal cyanide of Formula 3 and a compound of Formula 4. wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br, Cl or I; and R5, R6, R7, R8, R9 and R10 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 4 wherein R9 and R10 together are a cycloalkadiene bidentate ligand, comprising contacting a compound of Formula 5 wherein Y is Cl, Br or I, with a cycloalkadiene bidentate ligand, at least one metal reducing agent and a nitrile solvent.Also disclosed is a method for preparing a compound of Formula 1 comprising preparing a compound of Formula 4 by contacting a compound of Formula 5 with a cycloalkadiene bidentate ligand and at least one metal reducing agent, and then contacting the reaction mixture comprising the compound of Formula 4 with a compound of Formula 2 and at least one alkali metal cyanide of Formula 3; and further disclosed is a method for preparing a compound of Formula 6 wherein R15, R16, R17 and Z are as defined in the disclosure using a compound of Formula 1, characterized by preparing the compound of Formula 1 by a method disclosed above.
Public/Granted literature
- US20110034695A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES Public/Granted day:2011-02-10
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