A semiconductor memory device includes a cell array including a plurality of unit cells, a first amplification circuit amplifying an input signal received from at least one unit cell among the unit cells, a signal transmission unit to transmit the signal to the first amplification circuit in response to a selection signal, first amplification control circuit to output a first amplification control signal controlling an amplification operation of the first amplification circuit, a second amplification circuit to amplify an output signal of the first amplification circuit, a second amplification control circuit to output a second amplification control signal controlling an amplification operation of the second amplification circuit, and a voltage adjustment circuit to adjust an internal voltage of the first amplification circuit in response to a voltage adjustment signal before the first and second amplification circuits perform the amplification operation.