Various embodiments of an internal multi-band antenna architecture for a mobile computing device are described. An internal antenna architecture for a mobile computing device may include multiple antenna elements, including a first internal antenna element configured to operate in a downlink frequency sub-band of at least one frequency band for communication in a first mode, and a second internal antenna element configured to operate in an uplink frequency sub-band of the at least one frequency band for communication in the first mode. Other embodiments are described and claimed.