Integrated circuit having a Microcontroller Unit and Methods of Operation therefore. An integrated circuit comprises a microcontroller unit with synchronous logic operably coupled to non-clocked intelligent logic. The non-clocked intelligent logic is arranged to autonomously monitor multiple events associated with an operation of the synchronous logic and, in response thereto, the non-clocked intelligent logic initiates autonomously an alternate operational mode of the microcontroller unit. A method of operating a microcontroller unit is also described.