A user interface for display or editing of a three dimensional medical image is provided on a display and is responsive to user inputs in a medical imaging system. The user interface includes a framing tool for defining a region of interest on the medical image. An image matrix is then provided on the user interface, which includes a plurality of cross-sectional images each corresponding to a cross-section of the medical image at one of a plurality of cut planes within the region of interest. One or more reference views of the medical image are also displayed, which each include a plurality of reference indicia, each of which corresponds to a location of one of the plurality of cut planes.