A system and method for speculative assistance to a thread in a heterogeneous processing environment is provided. A first set of instructions is identified in a source code representation (e.g., a source code file) that is suitable for speculative execution. The identified set of instructions are analyzed to determine the processing requirements. Based on the analysis, a processor type is identified that will be used to execute the identified first set of instructions based. The processor type is selected from more than one processor types that are included in the heterogeneous processing environment. The heterogeneous processing environment includes more than one heterogeneous processing cores in a single silicon substrate. The various processing cores can utilize different instruction set architectures (ISAs). An object code representation is then generated for the identified first set of instructions with the object code representation being adapted to execute on the determined type of processor.