A self-lubricating mechanism of slide member, including a slide assembly and a lubricating section. The slide assembly has a linear guide section, a slider linearly slidably mounted on the guide section and reciprocally movable between a first position and a second position and at least one rolling section positioned in a space defined between the slider and the guide section. The lubricating section has a main body fixedly disposed on one side of the slider. The main body is formed with an internal oil reservoir and at least one passage in communication with the oil reservoir. The passage has an opening formed on a first side of the main body in communication with the space. A push body is retractably disposed on the main body. A stopper body is fixed in a position adjacent to the first position for retracting the push body to drive the oil into the space.