Invention Grant
US08216781B2 Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
有权
基因多态性作为肿瘤进展的预测因子及其在癌症治疗中的应用
- Patent Title: Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
- Patent Title (中): 基因多态性作为肿瘤进展的预测因子及其在癌症治疗中的应用
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Application No.: US12523521Application Date: 2008-01-17
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Publication No.: US08216781B2Publication Date: 2012-07-10
- Inventor: Heinz-Josef Lenz , Wu Zhang
- Applicant: Heinz-Josef Lenz , Wu Zhang
- Applicant Address: US CA Los Angeles
- Assignee: University of Southern California
- Current Assignee: University of Southern California
- Current Assignee Address: US CA Los Angeles
- Agency: Foley & Lardner LLP
- Agent Antoinette F. Konski; Alex Y. Nie
- International Application: PCT/US2008/000651 WO 20080117
- International Announcement: WO2008/088855 WO 20080724
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The invention provides compositions and methods for determining the likelihood of successful treatment with a pyrimidine based antimetabolite chemotherapy drug and a platinum based chemotherapy drug, such as 5-FU/oxaliplatin. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.
Public/Granted literature
- US20100113459A1 Gene Polymorphisms as Predictors of Tumor Progression and Their Use in Cancer Therapy Public/Granted day:2010-05-06
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