Invention Grant
US08216783B2 Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors
失效
肿瘤中酪氨酸激酶受体FGFR4的过表达和突变
- Patent Title: Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors
- Patent Title (中): 肿瘤中酪氨酸激酶受体FGFR4的过表达和突变
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Application No.: US12423750Application Date: 2009-04-14
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Publication No.: US08216783B2Publication Date: 2012-07-10
- Inventor: Javed Khan , James G. Taylor, VI , Tai Cheuk
- Applicant: Javed Khan , James G. Taylor, VI , Tai Cheuk
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; G01N33/53
Abstract:
This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR4 variants, which are linked to increased risk of tumor metastasis. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.
Public/Granted literature
- US20090258369A1 OVER-EXPRESSION AND MUTATION OF A TYROSINE KINASE RECEPTOR FGFR4 IN TUMORS Public/Granted day:2009-10-15
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