Invention Grant
- Patent Title: Compositions and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene
- Patent Title (中): 用于检测和治疗与人类转酮酶样-1基因过表达相关的增殖异常的组合物和方法
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Application No.: US12615592Application Date: 2009-11-10
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Publication No.: US08216792B2Publication Date: 2012-07-10
- Inventor: Johannes Coy
- Applicant: Johannes Coy
- Agency: Agris & von Natzmer LLP
- Agent Joyce von Natzmer
- Priority: EP02008831 20020419
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
Methods for in vitro diagnosis of carcinoma are disclosed. In one aspect the invention relates to methods such as detecting the level of transketolase like-1 polypeptide, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.
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