Invention Grant
- Patent Title: Polyene diester antibiotics
- Patent Title (中): 多烯二酯抗生素
-
Application No.: US12671024Application Date: 2007-07-30
-
Publication No.: US08217013B2Publication Date: 2012-07-10
- Inventor: Wenmei Wang , Wang Shuhui , Li Ji'an
- Applicant: Wenmei Wang , Wang Shuhui , Li Ji'an
- Applicant Address: CN Shanghai
- Assignee: Shanghai Institute of Pharmaceutical Industry
- Current Assignee: Shanghai Institute of Pharmaceutical Industry
- Current Assignee Address: CN Shanghai
- Agency: Syndicated Law
- Agent Brian S. Boyer
- International Application: PCT/CN2007/070382 WO 20070730
- International Announcement: WO2009/015541 WO 20090205
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H17/08
Abstract:
The present invention discloses a new polyene diester and its preparation. This polyene diester has a structure of Formula 1, which is used as prodrugs by introducing diester group to polyene antibiotics, and these prodrugs exhibit antifungal or antiviral activities through releasing parent polyenes by esterase in vivo. The new derivatives have good antimicrobial activity and better safety. These new derivatives are useful for the antifungal and antiviral treatment. PA-COOR Formula 1
Public/Granted literature
- US20100210576A1 POLYENE DIESTER ANTIBIOTICS Public/Granted day:2010-08-19
Information query
