Invention Grant
- Patent Title: Liquid phase peptide synthesis of KL-4 pulmonary surfactant
- Patent Title (中): KL-4肺表面活性剂的液相肽合成
-
Application No.: US12241171Application Date: 2008-09-30
-
Publication No.: US08217142B2Publication Date: 2012-07-10
- Inventor: Ahmed F. Abdel-Magid , Urs Eggmann , Cynthia Anne Maryanoff , Adrian Thaler , Frank J. Villani
- Applicant: Ahmed F. Abdel-Magid , Urs Eggmann , Cynthia Anne Maryanoff , Adrian Thaler , Frank J. Villani
- Applicant Address: US NJ Raritan
- Assignee: Ortho Pharmaceutical Corporation
- Current Assignee: Ortho Pharmaceutical Corporation
- Current Assignee Address: US NJ Raritan
- Main IPC: C07K1/06
- IPC: C07K1/06 ; C07K1/02
Abstract:
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.
Public/Granted literature
- US20090259021A1 Liquid Phase Peptide Synthesis of KL-4 Pulmonary Surfactant Public/Granted day:2009-10-15
Information query
